B. Carboxypenicillin: Under this classification, Carbenicillin comes first, of which, special feature is the activity against Pseudomonas aeruginosa and indole positive Proteus which are not inhibited by PnG or aminopenicilins. The certain features are:
1. It's neither penicillinase-resistant nor acid resistant.
2. It's inactive orally and is excreted rapidly in urine.
3. It’s t1/2 is 1 hour.
4. It's used as sodium salt in a dose of 1-2 g i.m. or 1-5 g i.v. every 4-6 hours. At higher doses , enough Na may be administered to cause fluid retention and CHF in patients with borderline renal or cardiac function.
C. Ureidopenicillins: Under this classification, Piperacillin is the first one to be discussed and there features are:
1. This antipseudomonal penicillin is about 8 times more active than carbenicillin.
2. It has goo activity against Klebsiella, many Enterobacteriaceae and some Bacteroides.
3. It is frequently employed for treating serious gram-negative infections in neutroponic/immunocompromised or burn patients.
4. Elimination t1/2 is 1 hours.
Dose: 100-150 mg/kg/day in 3 divided doses.
1. It's neither penicillinase-resistant nor acid resistant.
2. It's inactive orally and is excreted rapidly in urine.
3. It’s t1/2 is 1 hour.
4. It's used as sodium salt in a dose of 1-2 g i.m. or 1-5 g i.v. every 4-6 hours. At higher doses , enough Na may be administered to cause fluid retention and CHF in patients with borderline renal or cardiac function.
C. Ureidopenicillins: Under this classification, Piperacillin is the first one to be discussed and there features are:
1. This antipseudomonal penicillin is about 8 times more active than carbenicillin.
2. It has goo activity against Klebsiella, many Enterobacteriaceae and some Bacteroides.
3. It is frequently employed for treating serious gram-negative infections in neutroponic/immunocompromised or burn patients.
4. Elimination t1/2 is 1 hours.
Dose: 100-150 mg/kg/day in 3 divided doses.
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