Scaffold Hopping in the drug discovery

Drug discovery and development process has been advancing with the help of modern concept based techniques aiming to achieve both intellectual property of interest and self-sufficient in vivo optimization. The importance of Intellectual property will be discussed in coming article and how it boosts the discovery phase effectively is must know concept from research viewpoint. However, drugs are small molecules that fit inside the body as it comprises of thousands of receptors and enzymes providing numerous binding sites, but, these small molecules have few serious problematic features in them.

PHARMACEUTICAL AND FORMULATIONS CONSIDERATIONS (PART-2)

Hello, readers, today, I will be posting some interesting facts regarding principal of pH rules. So, first of all, what do you mean by the term pH? , or, why particularly is it used? I bet few people know the exact meaning of it, yet, it is as simple as tricky. Anyway, p comes as power, and, H, as, a symbol of Hydrogen, together, it is defined as a degree of power of hydrogen regarding the measurement of acidity of a solution which is related to the temperature coefficient. For instance, cherry syrup is acidic, or, when, the water is hot, a specific pH value gives the same relative point of reference, thus providing two ways to justify it as either "The cherry syrup has a pH of 3.5" or "the water is at 80 degree Celsius". If we look closely both these statements clarify the definition. pH is defined in terms of the hydrogen ion activity: 

Pharmaceutical and Formulation Consideration (part-1)

Hello, readers, I'll be discussing few rules regarding pharmaceutical dosage formulation considerations which appear to be the most prominent key features and it will be consisting in a series so stay with me and explore more through my journey here.

Causes Of very common heart diseases

Hello, today I am about to point out few reasons which would be, up to some extent, responsible for very common Cardiovascular Diseases.

Congestive Heart Failure

It depends on two main factors which maintain heart pumping with more consistency and regularity. When these two factors are imbalanced, somewhat, heart pumping becomes irregular and leading to CHF. These two factors are mainly;