PHARMACEUTICAL AND FORMULATIONS CONSIDERATIONS (PART-2)

Hello, readers, today, I will be posting some interesting facts regarding principal of pH rules. So, first of all, what do you mean by the term pH? , or, why particularly is it used? I bet few people know the exact meaning of it, yet, it is as simple as tricky. Anyway, p comes as power, and, H, as, a symbol of Hydrogen, together, it is defined as a degree of power of hydrogen regarding the measurement of acidity of a solution which is related to the temperature coefficient. For instance, cherry syrup is acidic, or, when, the water is hot, a specific pH value gives the same relative point of reference, thus providing two ways to justify it as either "The cherry syrup has a pH of 3.5" or "the water is at 80 degree Celsius". If we look closely both these statements clarify the definition. pH is defined in terms of the hydrogen ion activity: 

pH equals the negative logarithm of the hydrogen ion activity, or the activity of the hydrogen ion is 10 raised to the exponent -pH. Measured concentration of hydrogen ion is effective in solution. Easy reference is made to the hydrogen ion when reference should be made to the hydronium ion(h3o+). It is a matter of convenience and brevity that only the hydrogen ion in mentioned, even, though it is normally in its solvated form.

Importance:

1. It is an important parameter of preformulation study regarding pharmaceutical formulations. 2. It is important to estimate the acidity of solution as well as the temperature at which solution maintains pH. Hope, this will make easy and clear to you and useful as well. For further articles like these please stay with this site. Thank you.