Before, studying transdermal drug delivery system, it is mandatory to have knowledge about various layers of skin, so that it will help you to understand the mechanism of drug delivery through the skin. There are several layers depicted in details, but, I shall point out important ones which are involved in this system. Anyway, skin mainly consists of three layers,
which I'll discuss briefly as follows,
1. EPIDERMIS: The epidermis is the outer layer of the skin which provides barrier to infection and several pathogens, and regulates water loss from the body to the environmentn through transepidermal water loss. It consists of two layers such as stratified layers of flattened cells and stratum corneum composed of columner cells which is considered rate determining step in case of drug penetration.
2. DERMIS: The dermis is a layer situated between the skin and subcutaneous tissues, that is divided into two categories such as papillary region and reticular dermis.
3. HYPODERMIS: It is the lower most layer of the skin connected to the systemic circulation and they are composed of adipose cells, macrophages and fibroblasts.
1. EPIDERMIS: The epidermis is the outer layer of the skin which provides barrier to infection and several pathogens, and regulates water loss from the body to the environmentn through transepidermal water loss. It consists of two layers such as stratified layers of flattened cells and stratum corneum composed of columner cells which is considered rate determining step in case of drug penetration.
2. DERMIS: The dermis is a layer situated between the skin and subcutaneous tissues, that is divided into two categories such as papillary region and reticular dermis.
3. HYPODERMIS: It is the lower most layer of the skin connected to the systemic circulation and they are composed of adipose cells, macrophages and fibroblasts.
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